Understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.
RESEARCH INTERESTS
Genetics of congenital heart disease
Molecular basis of normal and abnormal cardiac development
22q11 Deletion syndrome
RECENT PUBLICATIONS
Garg, V., "Insights into the Genetic Basis of Congenital Heart Disease" Cellular Molecular Life Sciences, 63(10):1141-1148, 2006
Garg, V, "Molecular Genetics of Aortic Valve Disease" Curr Opin in Cardiology, 21(3):180-184, 2006
Rajagopal, S.K., Ma, Q., Obler, D., Shen, J., Manichaikul, A., Tomita-Mitchell, A., Boardman, K, Briggs, C, Garg, V., Srivastava, D., Goldmuntz, E., Broman, K.W., Benson, D.W., Smoot, L., and Pu, W.T., "Spectrum of Heart Disease Associated with Murine and Human GATA4 Mutation" J Mol Cell Cardiol, 2007
Schluterman, M.K., Krysiak, A.E., Kathiriya, I.S., Abate, N., Chandalia, M., Srivastava, D., and Garg, V., "Screening and Biochemical Analysis of GATA4 Sequence Variations in Patients with Congenital Heart Disease" Am J Med Genet A, 143(8):817-823, April 2007
SIGNIFICANT PUBLICATIONS
Yamagishi H, Garg V, Matsuoka R, Thomas T and Srivastava D, "A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects" Science, 283:1158-1161, 1999
Garg, V., Yamagishi, C., Hu, T., Kathiriya, I.S., Yamagishi, H., and Srivastava, D., "Tbx1, a DiGeorge syndrome candidate gene, is regulated by Sonic Hedgehog during pharyngeal arch development" Developmental Biology, 235:62-73, 2001
Garg, V., Kathiriya, I.S., Barnes, R., Schluterman, M.K., King, I.N., Butler, C. A., Rothrock, C.R., Eapen, R.S., Hirayama-Yamada, K., Joo, K., Matsuoka, R., Cohen, J.C., and Srivastava, D, "GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5" Nature, 424(6947):443-447, 2003
Garg V and Srivastava D., "Genetic underpinnings of cardiogenesis and congenital heart disease" Molecular Cardiology, 2005
Garg, V., Muth, A.N., Ransom, J.F., Schluterman, M.K., Barnes, R., King, I.N., Grossfeld, P.D., and Srivastava, D, "Mutations in NOTCH1 Cause Aortic Valve Disease" Nature, 437(7056):270-74, 2005
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