Our interest is in the general area of nerve injury and repair with the long-term goal of understanding the molecular basis of neurite growth, axon guidance and target recognition, both during development and after injury. The multidisciplinary experimental approach that we follow incorporates concepts and tools from cell and molecular biology, biochemistry, mouse genetics, tissue engineering, electrophysiology, and nanobiology towards the generation of nerve repair strategies. Our research projects aim at uncovering the basic cellular and molecular mechanisms underlying the biology of nerve growth, and the implementation of improved nerve repair strategies.
RESEARCH INTERESTS
Spinal Cord Injury
Peripheral Nerve Regeneration
Regenerative Carbon Nanotubes Neurointerfaces
RECENT PUBLICATIONS
Romero MI, Lu Lin, Lush M, Lei L, Parada LF, Zhu Y, "Deletion of NF1 in Neurons Induces Increased Axon Collateral Branching in Vitro and in Vivo Following Injury" J Neuroscience, 27(8):2124-2134, February 2007
Benson MD, Romero MI, Lush ME, Lu QR, Henkemeyer M, Parada LF., "Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth" Proc Natl Acad Sci U S A., 102(30):10694-9, July 2005
Lei L, Laub F, Lush M, Romero M, Zhou J, Luikart B, Klesse L, Ramirez F, Parada LF., "The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons" Genes Dev, 1;19:1354-64., June 2005
Ma L, Harada T, Harada C, Romero M, Hebert JM, McConnell SK, Parada LF., "Neurotrophin-3 is required for appropriate establishment of thalamocortical connections" Neuron, 14;36(4):623-34., November 2002
SIGNIFICANT PUBLICATIONS
Yokoyama N. Romero MI*. Cowan CA. Galvan P. Helmbacher F. Charnay P. Parada LF. Henkemeyer M, "Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline." Neuron, 29(1):85-97, January 2001
Romero MI, Rangappa N, Garry MG, Smith GM., "Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy." J Neurosci., 1;21(21):8408-16., November 2001
Romero MI, Rangappa N, Li L, Lightfoot E, Garry MG, Smith GM, "Extensive Sprouting of Sensory Afferents and Hyperalgesia Induced by Conditional Expression of Nerve Growth Factor in the Adult Spinal Cord" The Journal of Neuroscience, 20:4435-4445, June 2000
Romero MI, Phelps CJ., "Identification of growth hormone-releasing hormone and somatostatin neurons projecting to the median eminence in normal and growth hormone-deficient Ames dwarf mice" Neuroendocrinology, 65(2):107-16, February 1997
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