Our laboratory has been studying the pathways and biochemical mechanisms controlling different forms of programmed cell death in mammalian cells. In collaboration with our colleagues, we have also been developing chemical compounds regulating these pathways both as laboratorial tools and drug candidates for treating human diseases in which the cell death pathway are defective. Inappropriate activation or suppression of cell death are associated with the pathogenesis of some of the most devastating human diseases, such as cancer, neurodegenerative disease, auto-immune disease, and ischemic stroke.
We have set out a variety of techniques involving biochemistry, molecular biology and cell biology in the laboratory. We hope to use the combination of these techniques to uncover the mystery of programmed cell death.
RESEARCH INTERESTS
Why and how cells die
RECENT PUBLICATIONS
Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander, Xiaodong Wang, Patrick G. Harran, "A Small Molecule Smac Mimic Potentiates TRAIL- and TNF-Mediated Cell Death" Science, 305(5689):1471-1474, September 2004
Xuejun Jiang, Hyun-Eui Kim, Hongjun Shu, Yingmin Zhao, Haichao Zhang, James Kofron, Jennifer Donnelly, Dave Burns, Shi-chung Ng, Saul Rosenberg, and Xiaodong Wang, "Distinctive roles of PHAP proteins and prothymosin-alpha in a death Regulatory Pathway." Science, 299:214-5, January 2003
SIGNIFICANT PUBLICATIONS
Chunying Du, Min Fang, Yucheng Li, Lily Li, and Xiaodong Wang, "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition." Cell, 102:33-42, 2000
Xuesong Liu, Caryn Naekyung Kim, Jie Yang, Ronald Jemmerson, and Xiaodong Wang, "Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c." Cell, 86:147-157, 1996
Xu Luo, Imawati Budihardjo, Hua Zou, Clive Slaughter, and Xiaodong Wang, "Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors." Cell, 94:481-490, 1998
Lai Wang, Fenghe Du, and Xiaodong Wang, "TNF-_ induces two distinct caspase-8 activation pathways" Cell, 133:693-703, May 2008
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