Validation of myocardial triglyceride in vivo in respect to: obesity, ethnicity, gender, and diabetes. The aim of this project is to determine the role of triglyceride deposits within myocardial cells with a focus on the development of cardiac spectroscopy to evaluate relationship between triglyceride content within cardiac muscle and myocardial function.
Response of myocardial triglyceride to pharmacological interventions or life style changes.
In vivo metabolism of hepatic triglyceride.
RESEARCH INTERESTS
Development of noninvasive, spectroscopic tests for ectopic triglyceride with applications to myocardium skeletal muscle and liver.
Research in the field of prevention of diabetes and heart failure.
RECENT PUBLICATIONS
Vega GL, Chandalia M, Szczepaniak LS, Grundy SM, "Effects of N-3 fatty acids on hepatic triglyceride content in humans" J Investig Med, 56(5):780-5, June 2008
Szczepaniak LS, Victor RG, Orci L, Unger RH, "Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America" Circ Res, 101(8):759-67, October 2007
Zib I, Jacob AN, Lingvay I, Salinas K, McGavock JM, Raskin P, Szczepaniak LS., "Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes" J Investig Med, 55(5):230-6, July 2007
McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, Levine BD, Raskin P, Victor RG, Szczepaniak LS., "Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study" Circulation, 116(10):1170-5, September 2007
Lingvay I, Raskin P, Szczepaniak LS, "Effect of insulin-metformin combination on hepatic steatosis in patients with type 2 diabetes" J Diabetes Complications, 21(3):137-42, May 2007
SIGNIFICANT PUBLICATIONS
Dobbins RL, Szczepaniak LS, Zhang W, McGarry JD, "Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion" Am J Physiol Endocrinol Metab, 284(4):E778-87, April 2003
LS Szczepaniak, EE Babcock, AD Sherry, C Malloy, "Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo" Magn Reson Med, 36:451, 1996
LS Szczepaniak, A Sargeson, M Tweedle, RG Bryant, "Nuclear Magnetic Spin-Relaxation of Water Protons Caused by Metal Cage Compounds" Bioconjugate Chemistry, 3:27, 1992
LS Szczepaniak, RG Bryant, "Proton Nuclear Relaxation in Aqueous Copper(II) Amine Chelate Solutions" Inorganica Chimica Acta, 184:7, 1991
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