The regulation of G protein signaling by RGS protein.
The role of PIP2 on the regulation of ROMK Channels function.
The relationship between endocytosis and ROMK protein trafficking.
Using patch clamp technique to recording Cl- currents in pancreatic and submandibular acinar and duct cells to understand the molecular mechanism underlying signal transduction in cells.
Studying the role of the newly discovered CFTR and ENaC in submandibular acinar and duct cells for the secretion.
RECENT PUBLICATIONS
Huang G, Yao J, Zeng W, Mizuno Y, Kamm KE, Stull JT, Harding HP, Ron D, Muallem S, "ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice." J Cell Sci, 119(Pt 1):153-61, January 2006
Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF, "STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels." Nat Cell Biol, 8(9):1003-10, September 2006
Kiselyov K, Wang X, Shin DM, Zang W, Muallem S, "Calcium signaling complexes in microdomains of polarized secretory cells." Cell Calcium, [Epub ahead of print] October 2006
Wang Y, Soyombo AA, Shcheynikov N, Zeng W, Dorwart M, Marino CR, Thomas PJ, Muallem S, "Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO(3)(-) secretion: relevance to cystic fibrosis." EMBO J, [Epub ahead of print] October 2006
Kim JY, Zeng W, Kiselyov K, Yuan JP, Dehoff MH, Mikoshiba K, Worley PF, Muallem S, "Homer 1 Mediates Store- and Inositol 1,4,5-Trisphosphate Receptor-dependent Translocation and Retrieval of TRPC3 to the Plasma Membrane." J Biol Chem, 281(43):32540-9, October 2006
SIGNIFICANT PUBLICATIONS
Lee MG, Xu X, Zeng W, Diaz J, Wojcikiewicz RJ, Kuo TH, Wuytack F, Racymaekers L, Muallem S, "Polarized expression of Ca2+ channels in pancreatic and salivary gland cells. Correlation with initiation and propagation of [Ca2+]i waves." J Biol Chem, 272(25):15765-70, June 1997
Xu X, Croy JT, Zeng W, Zhao L, Davignon I, Popov S, Yu K, Jiang H, Offermanns S, Muallem S, Wilkie TM, "Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells." J Biol Chem, 273(42):27275-9, October 1998
Zeng W, Lee MG, Yan M, Diaz J, Benjamin I, Marino CR, Kopito R, Freedman S, Cotton C, Muallem S, Thomas P, "Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells." Am J Physiol, 273(2 Pt 1):C442-55, August 1997
Lee MG, Wigley WC, Zeng W, Noel LE, Marino CR, Thomas PJ, Muallem S, "Regulation of Cl-/ HCO3- exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells." J Biol Chem, 274(6):3414-21, February 1999
Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff KA, Fisher SL, Ross EM, Muallem S, Wilkie TM, "The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling." J Biol Chem, 273(52):34687-90, December 1998
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