Studies in my laboratory are directed towards dissection of how signals derived from cells of the innate defense system affect the responses of immune cells with antigen-specific receptors. Specifically, we are investigating productive interactions between natural killer (NK) cells and antibody-secreting B lymphocytes that may be important for mounting effective immune responses against pathogens. These interactions are especially important when T cell responses are compromised but they may also modify the specific direction of T cell responses even when the latter system is intact. These interactions may also contribute to the development of B cell mediated autoimmunity. Ongoing experiments are also directed towards the identification of specific cell surface molecules involved in these interactions to better facilitate the dissection of in vivo responses.
RESEARCH INTERESTS
Immunology
RECENT PUBLICATIONS
67. Gao, N., T. Dang, W. A. Dunnick, J. T. Collins, B. R. Blazar and D. Yuan, "Receptors and counterreceptors involved in NK-B cell interactions" J. Immunology, 174:4113, 2001
68. Lu, M, M. Zhang, J. Weiss, M. Apicella, X-H Li, D. Yuan and R.S. Munford, "Taming the Humoral Immune Response to Gram-negative Bacteria." Nature Immunology, 6:989-994, 2005
Gao, N., P. Schwartzberg, J.A. Wilder, B.R. Blazar, and D.Yuan., "B Cell Induction of IL-13 Expression in NK cells: Role of CD244 and SLAM-associated protein" Journal of Immunology, 176:2758-2764, March 2006
Gao, N., P. Jennings, and D. Yuan, "Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes." Int Immunol, 20:645-657, 2008
Jennings, P., A. Chan, P. Schwartzberg, E.K. Wakeland, and D.Yuan, "Antigen Specific Responses and ANA production in B6.Sle1b mice: A role for SAP" J.Autoimmunity, in press 2008
SIGNIFICANT PUBLICATIONS
Gao, N., T. Dang., and D. Yuan, "Interferon-g dependent and independent induction of switch recombination by NK cells" J. of Immunology, 167:2011-2018, 2001
Gao, N., T. Dang, W. A. Dunnick, J. T. Collins, B. R. Blazar and D. Yuan., "Receptors and counterreceptors involved in NK-B cell interactions" Journal of Immunology, 174:4113, 2005
Dorothy Yuan, "Interactions between NK Cells and B Lymphocytes" Advances in Immunology, 84:1-42, 2004
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