1. The role of cytoskeletal proteins in signal transduction, hypertonic and oxidative stress. Molecular biology of cell motility. Structure function analysis of gelsolin and CapG, Ca2+ and phosphoinositide regulated actin modulating proteins. Role of these proteins in coordinating signal transduction and the effect of changing phosphoinositide levels on cell proliferation and cytoskeletal remodeling.
2. Isoform specific functions and regulations of phosphoinositide kinases that synthesize PIP2 and PI4P, with particular emphasis on their roles in membrane trafficking (from the plasma membrane and the trans Golgi networkand), cytoskeletal regulation and signaling.
3. Effects of thermal burn injury and oxidative stress on the endothelial cell actin cytoskeleton and phosphoinositide homeostasis.
RESEARCH INTERESTS
Phosphoinositide regulation of the actin cytoskeleton and apoptosis
Phosphoinositide regulation of the Golgi
Differential targeting of type II phosphatidylinositol 4 kinase alpha and beta to the Golgi and the plasma membrane
Role of the extracellular actin scavenging system and hypertonic resuscitation in protection against burn and oxidant injuries.
RECENT PUBLICATIONS
Heldwein EE, Macia E, Wang J, Yin HL, Kirchhausen T, Harrison SC, "Crystal structure of the clathrin adaptor protein 1 core." Proc Natl Acad Sci U S A, 101(39):14108-13, September 2004
Wang YJ, Li WH, Wang J, Xu K, Dong P, Luo X, Yin HL, "Critical role of PIP5KIγ87 in InsP3-mediated Ca2+ signaling." J Cell Biol, 167(6):1005-10, December 2004
Wang T, Chuang TH, Ronni T, Gu S, Du YC, Cai H, Sun HQ, Yin HL, Chen X, "Flightless I homolog negatively modulates the TLR pathway." J Immunol, 176(3):1355-62, February 2006
Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, Crnogorac-Jurcevic T, Yin HL, Costello E, "Pancreatic cancer cells overexpress gelsolin family capping proteins which contribute to their cell motility." Gut, [Epub ahead of print] July 2006
Yamamoto M, Chen MZ, Wang YJ, Sun HQ, Wei Y, Martinez M, Yin HL, "Hypertonic Stress Increases Phosphatidylinositol 4,5-Bisphosphate Levels by Activating PIP5KIbeta." J Biol Chem, 281(43):32630-8, October 2006
SIGNIFICANT PUBLICATIONS
Yin HL, Stossel TP, "Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein." Nature, 281(5732):583-6, October 1979
Kwiatkowski DJ, Stossel TP, Orkin SH, Mole JE, Colten HR, Yin HL, "Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain." Nature, 323(6087):455-8, October 1986
Robinson RC, Mejillano M, Le VP, Burtnick LD, Yin HL, Choe S, "Domain movement in gelsolin: a calcium-activated switch." Science, 286(5446):1939-42, December 1999
Rozelle AL, Machesky LM, Yamamoto M, Driessens MH, Insall RH, Roth MG, Luby-Phelps K, Marriott G, Hall A, Yin HL, "Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3." Curr Biol, 10(6):311-20, March 2000
Wang YJ, J Wang, HQ Sun, M Martinez, YX Sun, E Macia, T Kirchhausen, JA Albanesi, MG Roth, HL Yin, "Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi" Cell, 114:299-310, 2003
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