1. The role of cytoskeletal proteins in signal transduction, hypertonic and oxidative stress. Molecular biology of cell motility. Structure function analysis of gelsolin and CapG, Ca2+ and phosphoinositide regulated actin modulating proteins. Role of these proteins in coordinating signal transduction and the effect of changing phosphoinositide levels on cell proliferation and cytoskeletal remodeling.
2. Isoform specific functions and regulations of phosphoinositide kinases that synthesize PIP2 and PI4P, with particular emphasis on their roles in membrane trafficking (from the plasma membrane and the trans Golgi networkand), cytoskeletal regulation and signaling.
3. Effects of thermal burn injury and oxidative stress on the endothelial cell actin cytoskeleton and phosphoinositide homeostasis.
RESEARCH INTERESTS
Phosphoinositide regulation of the actin cytoskeleton and apoptosis
Phosphoinositide regulation of the Golgi
Differential targeting of type II phosphatidylinositol 4 kinase alpha and beta to the Golgi and the plasma membrane
Role of the extracellular actin scavenging system and hypertonic resuscitation in protection against burn and oxidant injuries.
RECENT PUBLICATIONS
Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL, "PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal" Mol Biol Cell, 18(7):2646-55, July 2007
Jung G, Wang J, Wlodarski P, Barylko B, Binns DD, Shu H, Yin HL, Albanesi JP, "Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIbeta" Biochem J, 409(2):501-9, January 2008
Li J, Yin HL, Yuan J, "Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity" J Cell Biol, 181(2):321-33, April 2008
Mao YS, Yamaga M, Zhu X, Wei Y, Sun HQ, Wang J, Yun M, Wang Y, Di Paolo G, Bennett M, Mellman I, Abrams CS, De Camilli P, Lu CY, Yin HL, "Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis" J Cell Biol, 184(2):281-96, January 2009
Barylko B, Mao YS, Wlodarski P, Jung G, Binns DD, Sun HQ, Yin HL, Albanesi JP, "Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIalpha" J Biol Chem, [Epub ahead of print] February 2009
SIGNIFICANT PUBLICATIONS
Yin HL, Stossel TP, "Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein" Nature, 281(5732):583-6, October 1979
Yu FX, Johnston PA, Sudhof TC, Yin HL, "gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein" Science, 250(4986):1413-5, December 1990
Muallem S, Kwiatkowska K, Xu X, Yin HL, "Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells" J Cell Biol, 128(4):589-98, February 1995
Rozelle AL, Machesky LM, Yamamoto M, Driessens MH, Insall RH, Roth MG, Luby-Phelps K, Marriott G, Hall A, Yin HL, "Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3" Curr Biol, 10(6):311-20, March 2000
Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL, "Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi" Cell, 114(3):299-310, August 2003
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