| RESEARCH OVERVIEW |
| |
|
Dr. White is the first holder of the Audre Newman Rapoport Distinguished Chair in Pediatric Endocrinology. Recruited to UT Southwestern in 1994 from Cornell University Medical College in New York City, he is a Professor of Pediatrics and directs the pediatric endocrinology program at UT Southwestern.
Dr. White holds undergraduate and medical degrees from Harvard University. He was a resident in pediatrics at Johns Hopkins Hospital and a research fellow in molecular biology at Rockefeller University. He was on the faculty at Cornell for 13 years and reached the rank of Professor of Pediatrics.
His laboratory has studied the molecular basis of several genetic diseases of steroid hormone synthesis and metabolism. Some of these diseases affect growth, sexual differention or the ability to conserve salt in the blood, whereas others cause high blood pressure. Most recently, he has branched into study of a very large cell-surface molecule that his laboratory discovered by accident. It is important for development of the nervous system; mutations in this protein cause seizures, deafness and progressive blindness.
Dr. White has received a number of awards and honors including the Ernst Oppenheimer Award of the Endocrine Society in 1991 and the Mead-Johnson Award of the Society for Pediatric Research in 1996. He has served on several advisory committees for the National Institutes of Health and several editorial boards. |
| |
|
RESEARCH INTERESTS |
| |
|
Genetic diseases of steroid hormone biosynthesis and metabolism |
|
Genetic diseases affecting blood pressure |
|
Type 1 diabetes |
|
Functional analysis of large G-protein coupled receptors |
| |
|
RECENT PUBLICATIONS
|
| |
|
Nikkila H. McMillan DR. Nunez BS. Pascoe L. Curnow KM. White PC., "Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain" Molecular Endocrinology, 14(9):1351-64, September 2000 |
 |
|
Felner EI. White PC., "Improving management of diabetic ketoacidosis in children" Pediatrics, 108(3):735-40, September 2001 |
|
|
McMillan DR. Kayes-Wandover KM. Richardson JA. White PC., "Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system" Journal of Biological Chemistry, 277(1):785-92, January 2002 |
 |
|
Kayes-Wandover KM. Tannin GM. Shulman D. Peled D. Jones KL. Karaviti L. White PC., "Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene" Journal of Clinical Endocrinology & Metabolism, 86(11):5379-82, November 2001 |
|
|
Kayes-Wandover KM. White PC., "Steroidogenic enzyme gene expression in the human heart" Journal of Clinical Endocrinology & Metabolism, 85(7):2519-25, July 2000 |
|
| |
|
SIGNIFICANT PUBLICATIONS
|
| |
|
White PC. Grossberger D. Onufer BJ. Chaplin DD. New MI. Dupont B. Strominger JL., "Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man" Proceedings of the National Academy of Sciences of the United States of America, 82(4):1089-93, February 1985 |
|
|
Pascoe L. Curnow KM. Slutsker L. Rosler A. White PC., "Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency" Proceedings of the National Academy of Sciences of the United States of America, 89(11):4996-5000, June 1992 |
|
|
Tusie-Luna MT. White PC, "Gene conversions and unequal crossovers between CYP21 (steroid 21-hydroxylase gene) and CYP21P involve different mechanisms" Proceedings of the National Academy of Sciences of the United States of America, 92(23):10796-800, November 1995 |
|
|
Mornet E. Dupont J. Vitek A. White PC., "Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)" Journal of Biological Chemistry, 264(35):20961-7, December 1989 |
|
|
Mune T. Rogerson FM. Nikkila H. Agarwal AK. White PC., "Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase" Nature Genetics, 10(4):394-9, August 1995 |
|
| |
|
Point and right click (click and hold for Mac users) your mouse on and select "Save this link (or target) as..." option to save the file to your local computer.
|
