The central focus of my research program is the cellular and molecular neuropathology of neurodegenerative disease, especially Alzheimer disease and related dementing disorders. Specific topics currently under investigation include (1) assessment of the role of neocortical synapse loss in production of clinical cognitive impairment, and (2) the effects of genetic risk factors for Alzheimer disease on synapse integrity.
RESEARCH INTERESTS
Alzheimer disease
Neurodegenerative disorders
Immunohistochemistry
Tissue microarray technology
Forensic neuropathology
RECENT PUBLICATIONS
Raghavan R, de Kruijff L, Sterrenburg MD, Rogers BB, Hladik CL, White CL III, "Alpha-synuclein expression in the developing human brain" Pediatr Dev Pathol, 7:506-516, 2004
Lipton AM, White CL III, Bigio EH, "Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration." Acta Neuropathol, 108:379-385, 2004
Gass J, Cannon A, Mackenzie IR, et al., "Mutations in progranulin are a major cause of ubiqutin-positive frontotemporal lobar degeneration" Hum Mol Genet, 15:2988-3001, 2006
Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A, "Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia" Hum Mutat, 29:512-521, 2008
Hatanpaa KJ, Bigio EH, Cairns NJ, Womack KB, Weintraub S, Morris JC, Foong C, Xiao G, Hladik C, Mantanona TY, White CL III, "TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a Midwest-Southwest Consortium for FTLD study" J Neuropathol Exp Neurol, 67:271-279, 2008
SIGNIFICANT PUBLICATIONS
Whitehouse PJ, Hedreen JC, White CL III, Price DL, "Basal forebrain neurons in the dementia of Parkinson disease" Ann Neurol, 13:243-248, 1983
Saper CB, German DC, White CL III, "Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer type: possible role in cell loss" Neurology, 35:1089-1095, 1985
German DC, White CL III, Sparkman DR, "Alzheimer’s disease: neurofibrillary tangles in nuclei that project to the cerebral cortex" Neuroscience, 21:305-312, 1987
Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C, "Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease" Proc Natl Acad Sci USA, 86:7611-7615, October 1989
de Lacoste MC, Whiet CL III, "The role of cortical connectivity in Alzheimer’s disease pathogenesis: a review and model system" Neurobiol Aging, 14:1-16, 1993
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