Research focuses on transcriptional regulation of the lipophilic surfactant proteins and the interaction of these proteins with lung structure and function, particularly as they relate to pulmonary fibrosis and emphysema.
RESEARCH INTERESTS
Transcriptional Regulation of Surfactant proteins
Severe Asthma
Idiopathic Pulmonary Fibrosis
RECENT PUBLICATIONS
Guo Y., Yang M.C., Weissler J.C., and Yang Y.S., "Modulation of PLAGL2 transactivation activity by Ubc9 coactivation not SUMOylation" Biochem Biophys Res Communications, 374:57--75, August 2008
Tsakiri,K.,Cronkhite,J.,Kuan,P.,Xing,C.,Raghu,G.,Weissler J.C., Rosenblatt R.,Shay,J.,Garcia, C.K., "Adult-onset pulmonary fibrosis caused by mutations in telomerase" PNAS, Vol 104, No. 18:7552-7557, May 2007
Guo,Y., Yang,M.C., Weissler, J.C., and Y.S. Yang, "Nuclear relocation of PLAGL2 modulates gene activity in hypoxic lung cells: a mechanism in maintaining SP-C expression" Biochem and Biophys Res Communications, 360 (3):659-665, August 2007
Yang, M.C., Guo,Y, Liu, C, Deng, F, Weissler J.C., and Y.S. Yang, "TTF-1/TAP26 Complex Differentially Modulates Surfactant Protein-B (SP-B) and -C (SP-C) Promoters in Lung Cells" Biochem and Biophys Res Communications, 344 (2):484-490, June 2006
M.C. Yang, J.C. Weissler, L.S. Terada, F. Deng, and Y.S. Yang, "Pleiomorphic Adenoma Gene-Like-2, a zinc finger protein, transactivates the Surfactant Protein-C promoter" Am J Respir Cell Mol Biol, 32(1):35-43, January 2005
SIGNIFICANT PUBLICATIONS
Nicod L., M.F. Lipscomb, G.B. Toews, and J.C. Weissler, "Separation of potent and poorly functional human lung accessory cells based on autofluorescence" J. Leukoc. Biol, 45:458-65, May 1989
Twigg H. L., M.F. Lipscomb, B. Yoffe, D. Barbaro, and J.C. Weissler, "Enhanced accessory cell function by alveolar macrophages from patients infected with the human immunodeficiency virus" Am. J Respir Cell Mol Biol, 1:391-400, January 1989
Yarbrough W. C., Wilkes D.S., and J.C. Weissler, "Inhibition of lymphokine activated killer cells by human pulmonary macrophages: discordance between expression of the beta chain of the IL-2 receptor and response to IL-2r" Am J Resp Cell Mol Biol, 10:184-91, October 1994
Wilkes D.S. and J.C. Weissler, "Alloantigen-induced immunoglobulin production in human lung: Differential effect of accessory cell subpopulations on IgG synthesis" Am J Resp Cell Mol Biol, 10:339-46, November 1994
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