Brain damage related to environmental toxin exposure
Narcolepsy
Sleep mechanisms and disorders
Depression/Anxiety
RECENT PUBLICATIONS
Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M, "Expression of poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat" J Neuroscience, 24:4469-4477, 2004
Willie JT, Chemelli RM, Sinton CM, Tokita, S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA, Leonard CS, Richardson JA, Hammer RE, Yanagisawa M, "Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes" Neuron, 38:715-730, 2003
Beuckmann CT, Sinton CM, Miyamoto N, Ino M, Yanagisawa M, "N-type calcium channel alpha1B subunit (Cav2.2) knock-out mice display hyperactivity and vigilance state differences" J Neuroscience, 23:6793-6797, 2003
Sinton CM, McCarley RW, "Neurophysiology and neuropsychiatry of sleep and sleep disorders" Neuropsychiatry, 2nd ed. Schiffer RB, Rao SM and Fogel BS, Editors, Philadelphia: Lippincott, Williams & Wilkins, 358-394, 2003
Shaffery JP, Sinton CM, Bissette G, Roffwarg HP, Marks GA, "Rapid eye movement sleep deprivation modifies expression of long-term potentiation in visual cortex of immature rats" Neuroscience, 110:431-443, 2002
SIGNIFICANT PUBLICATIONS
Sinton CM, McCarley RW, "Neuroanatomical and neurophysiological aspects of sleep: basic science and clinical relevance" Seminars Clinical Neuropsychiatry, 5:6-19, 2000
Sinton CM, Fitch TE, Petty F, Haley RW, "Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the rat" Toxicol Appl Pharmacol, 165:99-105, 2000
Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M, "Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation" Cell, 98:437-451, 1999
Sinton CM, Fitch TE, Gershenfeld HK, "The effects of leptin on REM sleep and slow wave delta in the rat are reversed by food deprivation" J Sleep Research, 8:197-203, 1999
Sinton CM, Jouvet M, "Paradoxical sleep and coping with environmental change" Behavioral Brain Research, 9:151-163, 1983
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