Dr. Petroll’s goal as a scientist is to apply his background as a biomedical engineer to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to students and post-docs in a collaborative, interdisciplinary research environment. Broadly, his research interests include corneal wound healing, imaging, cell motility and tissue engineering. The main focus of Dr. Petroll’s cell mechanics research is to use multidimensional time-lapse imaging to investigate how the biomechanical behavior of corneal fibroblasts is regulated by both biochemical and biophysical stimuli. Dr. Petroll also has a longstanding interest in the application of clinical confocal microscopy to assess the clinical responses to corneal infection, injury and refractive surgical procedures. Details of Dr. Petroll’s research program can be found on his laboratory web site (see link above).
RESEARCH INTERESTS
Cell Mechanics
Digital Imaging
Wound Healing
Confocal Microscopy
Corneal Cell Biology
SIGNIFICANT PUBLICATIONS
Petroll WM, Jester JV, Ma L, "Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts" J Cell Sci, 116:1481-1491, 2003
Petroll WM, Vishwanath M, Ma L, "Corneal fibroblasts respond rapidly to changes in local mechanical stress" Invest Ophthalmol Vis Sci, 45:3466-4374, 2004
Morishige N, Petroll WM, Nishida T, Kenney MC, Jester JV, "Non-invasive imaging of corneal stromal collagen using two photon generated second harmonic signals" J Cataract Refract Surg, 32:1784-1791, 2006
Kim A, Lakshman N, Petroll WM, "Quantitative assessment of local collagen matrix remodeling in 3-D culture: The role of Rho kinase" Exp Cell Res, 312:3683-3692, 2006
Petroll WM, Ma L, Kim A, Ly L, Vishwanath M, "Dynamic assessment of fibroblast mechanical activity during Rac-induced cell spreading in 3-D culture" J Cell Physiol, 217:162-171, 2008
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