Our laboratory uses mouse models to study the role of estrogens in the regulation of bone mass accrual and metabolism. We are particularly interested in gender specific effects of estrogens. Other studies in the lab are aimed at determining how estrogens regulate calcium handling in the kidney and gut.
RESEARCH INTERESTS
Mechanism underlining estrogens’ regulation of bone mass and metabolism
Tumor imaging
RECENT PUBLICATIONS
Coskun ZU, Stewart CE, Robinson M, Beisert G, Rivera FJ, Oz OK, "Fortuitous detection of Pseudoaneurysm by three-phase bone scan" Clinical Nuclear Medicine, 30:685-687, 2005
Zhang S, Cagatay T, Amanai M, Zhang M, Kline J, Castrillon DH, Ashfaq R, Oz OK, and Wharton KA, "Viable Mice with compound mutations in the Wnt/Dvl-pathway antagonists nkd1 and nkd2" Molecular and Cell Biology, 27:4454-64, June 2007
Orhan K. Oz, Asghar Hajibeigi, Kevin Howard, Carolyn L. Cummins, Monique van Abel, Rene J. M. Bindels, R. Ann Word, Makoto Kuro-o, Charles Y. C. Pak, Joseph E. Zerwekh, "Aromatase Deficiency Causes Altered Expression of Molecules Critical for Calcium Reabsorption in the Kidneys of Female Mice" Journal of Bone and Mineral Research, in press
SIGNIFICANT PUBLICATIONS
Moe OW, Zerwekh JE, Huang CL, Preisig PA, Oz OK, Pak CYC, "Pathogenesis of Primary Hypercalciuria" Clinical Cases in Mineral and Bone Metabolism, 1/1:13-19, 2004
Oz OK, Millsaps R, Welch R, Birch J, Zerwekh JE, "Expression of aromatase in the human growth plate" J Molec Endocrinol, 27/2:249-253, 2001
Oz OK, Zerwekh JE, Fisher C, Graves K, Nanu L, Millsaps R, Simpson ER, "Bone has a sexually dimorphic response to aromatase deficiency" J Bone Min Res, 15:507-513, 2000
Braasch DA, Paroo Z, Constantinescu A, Ren G, Oz OK, Mason RP, Corey DR, "Biodistribution of Phosphodiester and Phosphorothioate siRNA" Biorganic and Medicinal Chemistry Letters, 14:1139-1143, 2004
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