Dr. Levine is broadly interested in the adaptive capacity of the circulation and is especially interested in the cardiovascular adaptation to exercise training and deconditioning, aging, space flight, and high altitude. He leads a unique human physiology research program called the Institute for Exercise and Environmental Medicine located at Presbyterian Hospital of Dallas, which is dedicated to exploring the limits to human functional capacity in health and disease. He is the Cardiovascular Team Leader for the National Space Biomedical Research Institute and is funded by NASA and the National Institute of Aging.
RESEARCH INTERESTS
Cardiovascular adaption to exercise training/exercise physiology
Deconditioning (bedrest & spaceflight)
High Altitude Physiology
Circulatory control including autonomic function mechanism of orthostatic hypotension
Regulation of the cerebral circulation
RECENT PUBLICATIONS
Prasad A, Popovic ZP, Arbab-Zadeh A, Fu Q, Palmer DM, Dijk E, Garcia MJ, Thomas JD, Levine BD, "The effects of aging and physical activity on Doppler measures of diastolic function" American Journal of Cardiology, 99:1629-36, 2007
Zhang R, Levine BD, "Autonomic ganglionic blockade does not prevent reduction in cerebral blood flow velocity during orthostasis in humans" Stroke, 38 (4):1238-44,, 2007
Iwasaki K, Levine BD, Zhang R, Zuckerman JH, Pawelczyk JA, Diedrich A, Ertl AC, Cox JF, Giller CA, Ray CA, Lane LD, Buckey JC, Baisch F, Eckberg DL, Robertson D, Biaggioni I, Blomqvist G, "Human cerebral autoregulation before, during, and after spaceflight" Journal of Physiology, 579(3):799-810, 2007
Shibata S, Zhang R, Hastings J, Fu Q, Okazaki K, Iwasaki K, Levine BD, "A cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans" Am J Physiol: Heart and Circulatory Physiology, 291(5):H2142-51, 2006
SIGNIFICANT PUBLICATIONS
Levine, Pawelczyk JA, Ertl AC, Cox JF, et. al., "Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight" J of Physiology, 538:331-340, 2002
Levine BD, Stray-Gundersen J, "Living-high training low: effect of moderate-altitude acclimatization with low-altitude training on performance" J Appl Physiol, 83(1):102-112, 1997
Perhonen M, Zuckerman JH, Levine BD, "Deterioration of left ventricular chamber performance after bed rest: "Cardiovascular deconditioning" or hypovolemia?" Circulation, 103:1851-1857, 2001
Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thoma JD, Palmer DM, Levine BD, "Effect of Aging and Physical Activity on Left Ventricular Compliance" Circulation, 110 (13):1799-1805, 2004
Q, Zhang R, Witkowski S, Arbab-Zadeh A, Prasad A, Okazaki K, Levine BD, "Persistent sympathetic activation during chronic antihypertensive therapy: A potential mechanism for long term morbidity?" Hypertension, 45::513-521, 2005
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