Our laboratories are in the Division for Translational Research and McDermott Center for Human Growth and Development at UTSW and are inherently multi-disiplinary. Our research is in three areas: 1) applied computational biology, 2) advanced instrumentation development and 3) genetics, genomics and proteomics research that capitalizes on our software findings and instrumentation capabilities. With the software and instrumentation being developed in our lab we pursue independent research, work collaboratively with other faculty at UTSW and researchers off-campus and also attempt to make the results of our research available to the world to accelerate biomedical discovery and application. Additional information and our on-line computational resources can be found on the www at http://innovation.swmed.edu.
The currently active projects include: 1) Genomic analysis software for gene discovery (polymorphism prediction, genomics features extraction/correlation), 2) Expression and proteomics software (structure/function/variation correlation and structural databases), 3) Data mining (grammar induction) on terabyte-sized biomedical text datasets, and Duplicate article detection as demonstrated on the Deja Vu web site. 4) Computational modeling and experimental verification of quantitative traits in association with repeat polymorphisms in canines and humans, 5 ) A very high performance hyperspectral imaging microscope for cytogenetics, especially for early cancer diagnosis, 6) Advances in sequencing technology including a capillary sequencer (with Beckman Instruments), now focused on identification of SNPs and microsatellite polymorphisms involved in cancer and cardiac disease, 7) Construction of a variable light synthesizer to study melanoma, immune system modulation and tissue engineering using specific light spectra, 8) The development of phase controlled digital imaging with applications to megachannel switching and communications, information encryption and Holographic TV
Dr. Garner’s future goals can be broken into two components: 1) his personal laboratory research, 2) his desire to establish and lead a computational biology center.
RESEARCH INTERESTS
Applications of Genomics - Cancer and Cardiology research, Instrumentation, High-throughput analysis, Sequencing, Microarrays, ...
Applied Computational Biology - Gene Networks, Sequence Analysis, Expert Systems, Polymorphism prediction, Protein-RNA-DNA unification, Microarray design and analysis, Text data mining, ...
Bioinformatics
Genetics, Genomics, DNA repeats, cancer, heart disease
Data Mining driven Drug Discovery, text data mining including ethics studies
RECENT PUBLICATIONS
1. Deus HF, Stanislaus R, Veiga DF, Behrens C, Wistuba II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Chang A, Vogel LH, Almeida JS, "A Semantic Web management model for intergrative biomedical informatics" PLoS ONE, 3(8):e2946 PMID 18698535 August 2008
Errami M, Sun Z, Long TC, George AC and Garner HR, "De’ja’ Vu: a Database of Duplicate Citations in the Scientific Literature" Nucleic Acids Research, Annual database issue:epublished Aug. 30,2008, January 2009
Errami M, Galindo CL, Tassa AT, DiMaio JM, Hill JA, and Garner HR, "Doxycycline Attenuates Isoproterenol- and Transverse Aortic Banding- induced Cardiac Hypertrophy in Mice" J of Pharmacol Exp Ther., 324(3):1196-203, March 2008
5. Mark F. Burkart, Jonathan D. Wren, Jason I. Herschkowitz, Charles M. Perou and Harold R. Garner, "Clustering of Microarray-Derived Gene Lists through Implicit Literature Connections" Bioinformatics, 2007
8. Mounir Errami, Jonathan D. Wren, Justin M. Hicks and Harold R. Garner, "eTBLAST: A web server to identify expert reviewers, appropriate journals and similar publications" Nucleic Acids Research, July 2007
SIGNIFICANT PUBLICATIONS
Long T, Errami M, George A, Sun Z, Garner HR, "Responding to Possible Plagiarism" Science, Vol 323:1293-1294, March 2009
Errami M and Garner HG, "A tale of two citations in Medline" Nature, 542(7177):397-9, January 2008
Wren J, Forgacs E, Fondon III J, Pertsemlidis A, Cheng S, Gallardo T, Williams R S, Shohet R, Minna J, Garner HR, "Repeat Polymorphisms Within Gene Regions: Phenotypic and Evolutionary Implications" American Journal of Human Genetics, Vol. 67, No. 2:345-356, August 2002
Michael L. Huebschman, Bala Munjuluri and Harold R. Garner, "Dynamic Holographic 3-D Image Projection" Optics Express, Vol. 11, No 5:437-445, March 2003
John. W. Fondon, III and Harold R. Garner, "Molecular origins of rapid and continuous morphological evolution" PNAS, December 2004
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