My lab is focusing on determining the molecular basis of various adult pulmonary diseases, including pulmonary fibrosis, for which there are few available medical treatments. We have used genetic and genomic techniques to probe the molecular underpinnings of this disease. Through an integrated clinical, molecular and animal-based approach, we aim toward successful treatment of patients with pulmonary disease through a better understanding of disease pathogenesis, development of better tools to detect those at risk and identification of new targets for therapeutic intervention.
RESEARCH INTERESTS
Genetic Basis of Adult Pulmonary Diseases
Idiopathic Pulmonary Fibrosis
Human Genetics
Aging
Familial Spontaneous Pneumothorax
RECENT PUBLICATIONS
Wang, Y., Kuan, P.J., Xing, C., Cronkhite, J.T., Torres, F., Rosenblatt, R.L., DiMaio, J.M., Kinch, L.N., Grishin, N.V. and Garcia, C.K., "Genetic Defects in Surfactant Protein A2 Associated with Pulmonary Fibrosis and Lung Cancer" American Journal of Human Genetics, 84(1):52-59, 2009
Cronkite, J. T., Xing, C., Raghu, G., Chin, K., Torres, F., Rosenblatt, R. L., and Garcia, C. K., "Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis" Am. J. Resp. Crit. Care Med., 178:729-737, 2008
Garcia, C.K., Wright, W.E. and Shay, J.W., "Human Disease of Telomerase Dysfunction: Insights into Tissue Aging" NAR, 35:7406-7416, 2007
Tsakiri, K.D., Cronkhite, J.T., Kuan, P.J., Raghu, G., Weissler, J.C., Rosenblatt, R.L., Shay, J.W., and Garcia, C.K., "Adult-Onset Pulmonary Fibrosis Caused by Mutations in Telomerase" PNAS, 104:7552-7557, 2007
Graham, Randall B., Nolasco, Melissa, Peterlin, Borut and Garcia, Christine Kim, "Nonsense Mutations in Folliculin Presenting as Isolated Spontaneous Pneumothorax in Adults." American Journal of Respiratory and Critical Care Medicine, 172:39-44, 2005
SIGNIFICANT PUBLICATIONS
Christine Kim Garcia, Kenneth Wilund, Marcello Arca, Giovanni Zuliani, Renato Fellin, Mario Maioli, Sebastiano Calandra, Stefano Bertolini, Fausto Cossu, Nick Grishin, Robert Barnes, Jonathan C. Cohen, and Helen H. Hobbs, "Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein" Science, 292:1394-1398, May 2001
Christine Kim Garcia, Joseph L. Goldstein, Ravindra K. Pathak, Richard G. W. Anderson, and Michael S. Brown, "Molecular Characterization of a Membrane Transporter for Lactate, Pyruvate, and Other Monocarboxylates: Implications for the Cori Cycle" Cell, 76:865-873, March 1994
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