Kenney Marie Dixon-Pickens Distinguished Professorship in Multiple Sclerosis Research Irene Wadel and Robert I. Atha, Jr., Distinguished Chair in Neurology, in Honor of Elliot Frohman, M.D., Ph.D.
Dr. Frohman’s research is focused on the development of ophthalmological models from which to characterize the processes of neurodegeneration, neuroprotection, and neurorestoration in multiple sclerosis (MS). These studies utilize advanced retinal imaging techniques such as optical coherence tomography (OCT) and laser polarimetry (GDx) and non-conventional MRI techniques such as diffusion tensor and magnetization transfer imaging. Neuroprotection clinical trials aimed at demonstrating preservation of neurons and axons within the retina after acute optic neuritis in MS patients are currently underway.
RESEARCH INTERESTS
Multiple Sclerosis Clinical Trials
Neuro-Ophthalmology
Neuroradiology of MS
Neuroimmunology
Neurorehabilitation
RECENT PUBLICATIONS
Frohman, E.M., Costello, O., Zivadinov, R., Stuve, O., Conger, A., Winslow, H., Trip, A., Frohman, T.C., Balcer, L., "Optical coherence tomography in MS" Lancet Neurology, 5:853-863, 2006
Frohman, E.M., Costello, F., Stuve, O., et al, "Modeling axonal degeneration within the anterior visual system:Implications for demonstrating neuroprotection in MS" Arch Neurol, (in press) 2007
Frohman, E.M., Raine, C., Racke, M.K., "Multiple Sclerosis: The plaque and its pathogenesis" New England Journal of Medicine, 354:942-955, 2006
Davis, S., Frohman, T.C., Brown, M., Mills, D., Crandall, C., Stuve, O., Frohman, E.M., "Modeling the pathophysiology of Uhthoff’s phenomenon in multiple sclerosis" Neurology, 70:1098-1106, 2008
Gordon-Lipkin, E., Chodkowski, B.A., MS, Reich, D.S., Smith, S.A., Pulicken, M., Balcer, L.J., Frohman, E.M., Cutter, G., and Calabresi, P.A., "Retinal nerve fiber layer correlates with brain atrophy in multiple sclerosis" Neurology, 69:1603-1609, 2007
SIGNIFICANT PUBLICATIONS
Frohman, E.M., Goodin, D., Calabresi, P., et al, "The utility of MRI in suspeced MS. The Therapeutics and Technology Assessment Committee of the American Academy of Neurology." Neurology, 61:602-611, 2003
Frohman, E.M., Frohman, T.C., Zhang, H., Hawker, K., Racke, M.K., Frawley, W., Kramer, P.D., "Quantitative Oculographic Characterization of INO in MS." J Neurol Neurosurg Psychiatry, 73:51-55, 2002
Frohman, E.M., Brannon, K., Racke, M.K., Hawker, K.,, "Mycophenolate mofetil in MS" Clin Neuropharm, 27:80-83, 2004
Frohman, E.M., Raine, C. Racke, M.K., "Multiple Sclerosis: The plaque and its pathogenesis" New England Journal of Medicine, 354:942-955, 2006
Zaveri, M, Conger, A, Frohman, TC, Galetta, SL, Cutter, GR, Maguire, MG, Calabresi, PA, Balcer, LJ, Frohman, EM., "Retinal Imaging by Laser Polarimetry Corroborates OCT Evidence of Axonal Degeneration in MS." Archives of Neurology, in press 2008
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