CD8 T lymphocytes play a central role in adaptive immunity against intracellular parasites and tumors. We have recently described a novel function for these cells which is their role in providing innate immune protection against certain bacterial infections. We have demonstrated that antigen non-specific memory CD8 T cells can be activated by cytokines to secrete interferon-γ, which protects against infection against the intracellular bacterium, Listeria monocytogenes. Our current efforts are directed towards understanding how these cells are recruited to sites of infection, their interaction with other cells of the immune system, and other roles they may play in the innate immune response.
RESEARCH INTERESTS
class I antigens
CD8 T cells
NK cells
Innate immunity
NKT cells
RECENT PUBLICATIONS
Rance E. Berg, Emily Crossley, Sean Murray and James Forman, "Relative Contributions of NK and CD8 T cells to IFN-γ Mediated Innate Immune Protection against Listeria monocytogenes." J. Immunology Cover picture for the August 1 2005 issue of the Journal taken from this article., 175:1571, 2005
Su, Jie, Berg, R.E., Murray, S., and Forman, J, "Thymus-dependent memory phenotype CD8 T cells in naive B6.H-2Kb-/-Db-/- animals mediate an antigen-specific response against Listeria monocytogenes." J. Immunology, in press Fall 2005
Gunturi, A, Berg, R.E., Crossley, E., Murray, S. and Forman J., "The role of TCR stimulation and TGF-beta in controlling the expression of CD94/NKG2A receptors on CD8 T cells." European J. Immunology, 35:766-775, 2005
Cowley SC, Hamilton E, Frelinger JA, Su J, Forman J, Elkins KL., "CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo." J. Experimental Medicine, 202:309-319, 2005
Parisa Sinai, Rance E. Berg, J. Marshall Haynie, Merrill J. Egorin, Robert L. Ilaria Jr, and James Forman, "Imatinib mesylate inhibits antigen-specific memory CD8 T cell responses in vivo." J. Immunology, 178:2028-2037, February 2007
SIGNIFICANT PUBLICATIONS
Berg, R., Crossley, E., Murray, S. and Forman, J., "Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes" J. Experimental Medicine, 198:1583, 2003
Bai, A. and Forman, J., "The effect of the proteasome inhibitor lactacystin on the presentation of Tap-dependent and -independent peptide epitopes by class I molecules." J. Immunol., 159:2139-46, 1997
Bai, A., Broen, J and Forman, J., "The pathway for processing leader-derived peptides that regulate the maturation and expression of Qa-1b." Immunity, 9:413-421, 1998
Seaman, M., Wang, C.-R., and J. Forman., "MHC Class Ib Restricted CTL Provide Protection Against Primary and Secondary Listeria monocytogenes Infection." J. Immunology, 165:5192-5201, 2000
Aldrich, C.J., DeCloux, A., Woods, A.S., Cotter, R.J., Soloski, M., and Forman, J., "Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class IB antigen." Cell, 79:649-658, 1994
Aldrich, C.J., Hammer, R.E., Koszinowski, U., Hood, L., Stroynowski, I., and Forman, J., "Negative and positive selection of antigen-specific cytotoxic T lymhoyctes affected by the 3 domain of MHC I molecules." Nature, 352:718-721, 1991
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