Dr. de Lemos is an active investigator in the Donald W. Reynolds Cardiovascular Research Center at UT Southwestern, and also remains closely affiliated with the Thrombolysis in Myocardial Ischemia (TIMI) research group. His primary research interest is risk assessment and management of acute and chronic coronary artery disease. His other research interests include electrocardiography as a means of assessing the coronary microcirculation after thrombolysis or percutaneous coronary intervention, and the use of novel biomarkers for prognostic assessment among patients with coronary artery disease. He has worked extensively with novel biomarkers such as B-type natriuretic peptide, Monocyte Chemoattractant protein-1, and C-reactive Protein. He was recently the lead author of the Z phase of the A to Z trial, an international trial investigating different cholesterol lowering strategies in patients with acute coronary syndromes.
RESEARCH INTERESTS
Acute Coronary Sydromes
The Coronary Microcirculation
Cardiac Biomarkers
Lipid Lowering Therapy
Screening for Cardiovascular Disease
RECENT PUBLICATIONS
58. de Lemos, JA, Zirlik A, Schonbeck U, Varo N, Murphy S, Khera A, McGuire DK, Stanek G, Lo H, Nuzzo R, Morrow DA, Peshock R, Libby P., "Associations Between Soluble CD40 Ligand, Atherosclerosis Risk Factors, and Subclinical Atherosclerosis: Results from the Dallas Heart Study." ATVB, 25:2192-6, 2005
59. Abdullah SM, Khera A, Das SR, Stanek HG, Canham RM, Chung AK, Morrow DA, Drazner MH, McGuire DK, de Lemos JA, "Relation of Coronary Atherosclerosis Determined by Electron Beam Computed Tomography and Plasma Levels of N-terminal Pro-Brain Natriuretic Peptide in a Multiethnic Population-Based Sample (The Dallas Heart Study)" Am J Cardiol, 96:1284-9, 2004
60. Morrow DA, de Lemos JA, Blazing MA, Sabatine MS, Murphy SA, Jarolim P, White HD, Fox KAA, Califf RM, Braunwald E, "Prognostic Value of B-type Natriuretic Peptide During Follow-up of Patients with Unstable Coronary Artery Disease in the A to Z Trial" JAMA, 294:2866-71, 2005
64. Wallace TW, Abdullah S, Drazner MH, Das SR, Khera A, McGuire DK, Wians F, Sabatine MS, Morrow DA, de Lemos JA, "Prevalence and Determinants of Troponin T Elevation in the General Population" Circulation, 113:1958-65, 2006
70. de Lemos JA, Wiviott SD, Murphy SA, Blazing MA, Lewis EF, Califf RM. Pfeffer MA, Braunwald E, "Evaluation of the National Cholesterol Education Program Adult Treatment Panel III algorithm for selecting candidates for statin therapy: Insights from the A to Z trial" Am J Cardiol, 98:739-42, 2006
SIGNIFICANT PUBLICATIONS
de Lemos JA, Antman EM, Giugliano RP, McCabe CH, Murphy SA, Gibson CM, Braunwald E, "ST resolution and infarct related artery patency and flow after thrombolytic therapy" American Journal of Cardiology, 85:299-304, November 2000
de Lemos JA, Antman EM, Gibson CM, McCabe CH, Giugliano RP, Murphy SA, Coulter SA, Anderson K, Scherer J, Frey M, Van der Wieken R, Van de Werf F, MD, Braunwald E, "Abciximab improves both epicardial flow and myocardial reperfusion in ST elevation myocardial infarction: observations from the TIMI 14 trial" Circulation, 101:239-43, December 2000
de Lemos JA, Morrow DA, Bentley JH, Omland T, Sabatine MS, McCabe CH, Hall C, Cannon CP, Braunwald E, "The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes" New England Journal of Medcine, 345:1014-21, September 2001
46. de Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, Rouleau JL, Pedersen TR, Gardner LH, Mukherjee R, Ramsey KE, Palmisano J, Bilheimer DW, Pfeffer MA, Califf RM, Braunwald E, "Early Intensive vs a Delayed Conservative Simvastatin Strategy in Patients With Acute Coronary Syndromes: Phase Z of the A to Z Trial" JAMA, 292:1303-17, 2004
47. de Lemos JA, Blazing MA, Wiviott SD, Brady WE, White HD, Fox KAA, Palmisano J, Ramsey KE, Bilheimer D, Lewis EF, Califf RM, Braunwald E, "Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A to Z trial" Eur Heart J, 25:1688-94, 2004
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