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Melanie Cobb

 
 
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Melanie Cobb, Ph.D.

 Details of Research

Biographical Sketch Details of Research Personal Overview How to Contact
Melanie Cobb
Name:
  Melanie H. Cobb, Ph.D.
Academic Title:
  Professor
Primary Appointment:
  Pharmacology
Secondary Appointment:
  Graduate School of Biomedical Sciences Administration
School:
  Graduate School of Biomedical Sciences
Degree Program:
  Biological Chemistry
Cell Regulation
Integrative Biology

 RESEARCH INTERESTS
 
Protein kinase cascades
MAP kinases
Signal transduction in pancreatic beta cells
WNK protein kinases
Signaling specificity
 
 RECENT PUBLICATIONS
 
M. Raman, S. Earnest, K. Zhang, Y. Zhao, and M.H. Cobb., "TAOs mediate activation of p38 in response to DNA damage." EMBO J., 26:2005-2014, 2007
B-e. Xu, S. Stippec, P-Y. Chu, X-J. Li, A. Lazrak, B. Ortega, B-H. Lee, J.M. English, C. Huang, and M.H. Cobb., "WNK1 activates SGK1 to regulate the epithelial sodium channel." Proc. Natl. Acad. Sci., 102:10315-10320, 2005
B-H. Lee, X. Min, C.J. Heise, B-e. Xu, S. Chen, H. Shu, K. Luby-Phelps, E.J. Goldsmith, and M.H. Cobb., "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding." Molecular Cell, 15:741-751, 2004
 
 SIGNIFICANT PUBLICATIONS
 
T.G. Boulton, S.H. Nye, D.J. Robbins, N.Y. Ip, E. Radziejewska, S.D. Morgenbessor, R.A. DePinho, N. Panayotatos, M.H. Cobb and G.D. Yancopoulos., "ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF." Cell, 65:663-675, 1991
F. Zhang, A. Strand, D. Robbins, M.H. Cobb, and E.J. Goldsmith., "Atomic structure of the MAP kinase ERK2 at 2.3A resolution." Nature, 367:704-711, 1994
A. Khokhlatchev, B. Canagarajah, J. Wilsbacher, M. Robinson, M. Atkinson, E.J. Goldsmith, and M.H. Cobb., "Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation." Cell, 93:605-615, 1998
B-H. Lee, X. Min, C.J. Heise, B-e. Xu, S. Chen, H. Shu, K. Luby-Phelps, E.J. Goldsmith, and M.H. Cobb., "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding." Molecular Cell, 15:741-751, 2004
B-e. Xu, S. Stippec, P-Y. Chu, X-J. Li, A. Lazrak, B. Ortega, B-H. Lee, J.M. English, C. Huang, and M.H. Cobb., "WNK1 activates SGK1 to regulate the epithelial sodium channel." Proc. Natl. Acad. Sci., 102:10315-10320, 2005
 
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