I received my bachelor’s degree from Columbia College in 1979 and my Ph.D. in biology from Stanford University in 1988. During my postdoctoral research here in the Department of Pharmacology at UT Southwestern, my interest in signal transduction was focused on cell signaling mechanisms mediated by heterotrimeric G proteins. In 1994, I joined the Department of Biological Chemistry at the University of Michigan Medical Center, where I initiated genetic studies on the hormone regulated adenylyl cyclase system. Following my promotion to associate professor in 2001, I moved back to Dallas, joining the UT Southwestern Pharmacology faculty. My laboratory continues our long-established interest in understanding signal transduction processes regulated by heterotrimeric G proteins, with the primary focus of our research being the hormone regulated adenylyl cyclase system. These studies utilize a combination of molecular biology, biochemical and genetic approaches. Our most recent efforts have focused on determining the involvement of adenylyl cyclase mutations in pathophysiological states and examining the oncogenic potential of activating mutant adenylyl cyclase alleles. In addition to my laboratory research interests, I am the associate director of the Alliance for Cellular Signaling, a multi-institutional effort based here at UT southwestern that is aimed at understanding signaling networks in mouse macrophages.
