Dr. Mayo obtained her B.A. degree in Psychology from Northwestern University; Evanston, Illinois in 1986. She obtained her M.D. degree from Baylor College of Medicine; Houston, Texas in 1990. After her internship and residency in Internal Medicine at University of California, Irvine, California (1990-1993), she completed a fellowship in Gastroenterology/Hepatology at the University of Texas Southwestern Medical Center at Dallas, Texas (1993-1996). Dr. Mayo specializes in the diagnosis and management of acute and chronic liver diseases, and she enjoys establishing a friendly and supportive relationship with her patients. Dr. Mayo has a keen interest in immune-mediated liver diseases such as primary biliary cirrhosis, autoimmune hepatitis, autoimmune cholangitis, overlap syndromes, and. cryoglobulinemia. She also has a special interest in the management of itching from liver disease. In the laboratory, Dr Mayo's research focuses on the pathogenesis of autoimmune liver diseases. The molecular events involved in bile duct damage in primary biliary cirrhosis and development of cryoglobulins in hepatitis C are current areas of investigation. She studies how the T cell receptor and other co-stimulatory molecules on the surface of B and T lymphocytes participate in the genesis and chronic perpetuation of autoimmune diseases. Dr. Mayo also conducts clinical trials in the University of Texas Southwestern General Clinical Research Center investigating new treatments for primary biliary cirrhosis.