Our laboratory is interested in molecular signaling processes in cardiac hypertrophy and failure. Using molecular, physiological, and electrophysiological approaches, we study mechanisms of structural, functional, and electrical remodeling in heart disease. These studies are based on genetic and surgical models of heart disease in animals, as well as patients with hypertrophic heart disease and cardiomyopathy. Specific questions we are studying at present include:
- mechanisms governing the pathological growth response of the myocardium
- autophagy as a novel mechanism of remodeling that contributes to the transition from stable hypertrophy to heart failure
- mechanisms of Ca2+ metabolism in hypertrophied and failing ventricular myocytes with particular emphasis on transcriptional and post-translational regulation of the L-type Ca2+ channel
- phosphoinositide-dependent signaling pathways (and downstream targets) in cardiac hypertrophy and failure
RESEARCH INTERESTS
cardiac hypertrophy and failure
electrophysiological remodeling
molecular signaling
RECENT PUBLICATIONS
Wang, Z., Kutschke, W., Richardson, K.E., Karimi, M., and Hill, J.A., "Electrical remodeling in pressure-overload cardiac hypertrophy: Role of calcineurin." Circulation, 104:1657-1663, 2001
Rothermel, B.A., Berenji, K., Tannous, P., Kutschke, W., Dey, A., Nolan, B., Yoo, K.-D., Demetroulis, E., Gimbel, M., Cabuay, B., Karimi, M., Hill, J.A., "Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure" Physiol Genomics, 23:18-27, July 2005
Ni, Y.G., Berenji, K., Wang, N., Oh, M., Sachan, N., Dey, A., Cheng, J., Lu, G., Morris, D.J., Castrillon, D., Gerard, R.D, Rothermel, B.A., Hill, J.A., "Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling." Circulation, 114:1159-1168, 2006
Kong, Y., Lu, G., Tannous, P., Berenji, K., Rothermel, B.A., Olson, E.N., Hill, J.A., "Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy." Circulation, 113:2579-2588, 2006
Wang, Y., Cheng, J., Joyner, R.W., Wagner, M.B., Hill, J.A., "Remodeling of early-phase repolarization: A mechanism of abnormal impulse conduction in heart failure" Circulation, 113:1849-1856, 2006
SIGNIFICANT PUBLICATIONS
Zhu, H., Tannous, P., Johnstone, J.L., Kong, Y., Shelton, J.M., Richardson, J.A., Levine, B., Rothermel, B.A., Hill, J.A., "Cardiac autophagy is a maladaptive response to hemodynamic stress" J Clin Invest, 117(7):1782?1793, July 2007
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