Congenital anomalies of the genitourinary tract are extremely common and unfortunately poorly understood. In Dr. Linda Baker’s NIH-funded laboratory, the molecular basis of these diseases are investigated using a combined approach of genetically engineered mouse models of congenital disease and translational research employing human samples from affected patients. Specific disease entities under investigation include hypospadias, imperforate anus, cryptorchidism, intersex states, specific human chromosomal disorders, and urinary stone disease. Through this research, we strive to improve the lives of children affected with these genitourinary birth defects.
RESEARCH INTERESTS
Inherited or familial birth defects of the genitourinary tract
Causes of undescended testes and testicular torsion
Causes of hypospadias
Pediatric renal stone disease
Causes of intersex disorders
RECENT PUBLICATIONS
Baker LA, Jacobson KC, Raine A, Lozano DI, Bezdjian S, "Genetic and environmental bases of childhood antisocial behavior: a multi-informant twin study" Journal of Abnormal Psycology, 116(2):219-35, May 2007
Dodson JL, Baird AD, Baker LA, Docimo SG, Mathews RI, "Outcomes of delayed hypospadias repair: implications for decision making" Journal of Urology, 178(1):278-81, July 2007
Cameron MA, Baker LA, Maalouf NM, Moe OW, Sakhaee K, "Circadian variation in urine pH and uric acid nephrolithiasis risk" Nephrol Dial Transplant, 22(8):2375-8, August 2007
Jenkins D, Bitner-Glindzicz M, Thomasson L, Malcolm S, Warne SA, Feather SA, Flanagan SE, Ellard S, Bingham C, Santos L, Henkemeyer M, Zinn A, Baker LA, Wilcox DT, Woolf AS, "Mutational analyses of UPIIA, SHH, EFNB2 and HNF1beta in persistent cloaca and associated kidney malformations" Journal of Pediatric Urology, 3(1):2-9, February 2007
Garcia NM, Allgood J, Santos LJ, Lonergan D, Batanian JR, Henkemeyer M, Bartsch O, Schultz RA, Zinn AR, Baker LA, "Deletion Mapping of Critical Region for Hypospadias Penoscrotal Transposition and Imperforate Anus on Human Chromosome 13" Journal of Pediatric Urology, 2(4):233-242, August 2006
SIGNIFICANT PUBLICATIONS
Karam, J. A. and Baker, L. A., "True Hermaphrodite." New Engl J Med, 350:393, May 2004
Baker, L.A., Zhang, S., Nef, S., Nguyen, M., Pohl, H., and Parada, L.F., "The Insulin-3(INSL3) Gene: Lack of a genetic basis for human cryptorchidism" J Urol, 167(6):2534-7, 2002
Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RS, Baker LA, Srivastava D, and Henkemeyer M, "Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development" Dev Biol, 271(2):263-271, 2004
Baker, L.A., Docimo, S.G., Peters, C., Cisek, L., Diamond, D.A., Caldamone, A., Koyle, M., Strand, W., Moore, R., Mevorach, R., Brady, J., Jordan, G., Erhard, M., Surer, I., Franco, I., "A Multi-Institutional analysis of laparoscopic orchidopexy" Br J Urol International, 87(6):484-9, 2001
Garcia NM, Allgood J, Santos LJ, Lonergan D, Batanian JR, Henkemeyer M, Bartsch O, Schultz RA, Zinn AR, Baker LA, "Deletion Mapping of Critical Region for Hypospadias Penoscrotal Transposition and Imperforate Anus on Human Chromosome 13" Journal of Pediatric Urology, 2(4):233-242, August 2006
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