Mechanisms of G protein-mediated signal transduction
Integration of biological signaling
Interaction of membrane-bound enzymes and hormone receptors
Structure of G protein-coupled receptors
Computational modeling of signaling networks
RECENT PUBLICATIONS
Ilkaeva, O., Kinch, L.N., Paulssen, R.H., and Ross, E.M., "Mutations Of The Carboxyl Terminal Domain Of Phospholipase C-β1 Delineate The Dimer Interface And A Potential Gαq Interaction Site" J. Biol. Chem., 277:4294-4300, February 2002
Mukhopadhyay, S., and Ross, E.M., "Rapid GTP binding and hydrolysis by Gq promoted by receptor and GTPase-activating proteins" Proc. Natl. Acad. Sci. USA, 96:9539-9544, August 1999
Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R., "Uncoupling Conformational Change From GTP Hydrolysis In A Heterotrimeric G Protein alpha Subunit. Proc." Proc.Natl. Acad. Sci., 101:7560-7565, March 2004
Tang, W., Tu,Y., Nayak, S.K., Woodson J., Jehl, M. and Ross, E.M., "G&beta&gamma Inhibits G&alpha-GTPase-activating Proteins (GAPs) by Inhibition of G&alpha-GTP Binding during Stimulation by Receptor" J. Biol. Chem., 281:4746-4753, 2006
Turcotte, M., Tang, W., Ross, E.M., "Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP" PLoS Computational Biology, 4:e100148, August 2008
SIGNIFICANT PUBLICATIONS
Ross, E.M., and Wilkie, T.M., "GTPase-activating Proteins (GAPs) For Heterotrimeric G Proteins: Regulators Of G Protein Signaling (RGS) And RGS-like Proteins" Annu. Rev. Biochem., 96:795-827, 2000
Wang, J., Ducret, A., Tu, Y., Kozasa, T, Aebersold, R., and Ross, E.M., "RGSZ1, A Gz-Selective RGS Protein in Brain: Structure, Membrane Association, Regulation by Gαz Phosphorylation, and Relationship to a Gz GTPase-Activating Protein Subfamily" J. Biol. Chem., 273:26014-26025, October 1998
Tu, Y., Wang, J., and Ross, E.M., "Inhibition of Brain Gz GAP and Other RGS Proteins by Palmitoylation of Protein α Subunits" Science, 278:1132-1135, November 1997
Biddlecome, G.H., Berstein,G., and Ross, E.M., "Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor: Steady-State Balance of Receptor-Mediated Activation and GAP-Promoted Deactition" J. Biol. Chem., 271:7999-8007, April 1996
Berstein, G., Blank, J.L., Jhon, D-Y., Exton, J.H., Rhee, S.G., and Ross, E.M., "Phospholipase C-β1 is a GTPase Activating Protein for Gq/11, its Physiologic Regulator" Cell, 70:411-418, August 1992
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