The focus of our research is directed at understanding human CD4+ T cell activation and cytokine production. Recent studies are focused on dissecting the mechanisms involved in the development of T helper-1 (Th-1) proinflammatory effector cells that secrete interferon-gamma, Th-2 effector cells that secrete cytokines such as IL-4 and regulatory T cells that downregulate inflammatory responses. Another goal is to identify T cell surface markers and intracellular molecules that correlate with activation states or stages of post-thymic differentiation. Information gained from these studies is applied to investigations of chronic inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. These studies will lead to a better understanding of the mechanisms involved in autoimmunity.
RESEARCH INTERESTS
T Lymphocyte Activation
Molecular Mechanisms Inducing Autoimmunity
RECENT PUBLICATIONS
Han B.K., A.M. White, K.H. Dao, D.R. Karp, E.K. Wakeland, L.S. Davis, "Increased prevalence of activated CD70+ CD4+ T cells in the periphery of patients with systemic lupus erythematosus" Lupus, 14:598-606, 2005
King, M.R., A.S. Ismail, L.S. Davis, D.R. Karp, "Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype" J. Immunol., 176 (5):2765-2772, March 2006
Hutcheson J, Scatizzi JC, Siddiqui AM, Haines GK 3rd, Wu T, Li QZ, Davis LS, Mohan C, Perlman H., "Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity." Immunity, 28:206-217, February 2008
Wu T, Qin X, Kurepa Z, Kumar KR, Liu K, Kanta H, Zhou XJ, Satterthwaite AB, Davis LS, Mohan C., "Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus." J. Clin. Invest., 117(8):2186-2196, August 2007
Cravens PD, Hayashida K, Davis LS, Nanki T, Lipsky PE., "Human peripheral blood dendritic cells and monocyte subsets display similar chemokine receptor expression profiles with differential migratory responses." Scand. J. Immunol., 65(6):514-524, June 2007
SIGNIFICANT PUBLICATIONS
A.F. Kavanaugh, L.S. Davis, L.A. Nichols, S.H. Norris, R. Rothlein, L.A. Scharschmidt, and P.E. Lispky, "Treatment of regractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule-1 (ICAM-1)" Arthritis and Rheumatism, 37:992-999, 1994
Schulze-Koops, H., P.E. Lipsky, and L.S. Davis, "Differentiation of human memory T cells into Th2-like effector cells is dependent on IL-4 and CD28 stimulation and inhibited by T cell receptor ligation" European Journal of Immunology, 28:2517-2529, 1998
R. Thomas, L.S. Davis, and P.E. Lipsky, "Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells" Journal of Immunology, 152:2613-2623, 1994
L.S. Davis, A.F. Kavanaugh, L.A. Nichols, and P.E. Lipsky, "Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis" Journal of Immunology, 154:3523-3537, 1995
Davis, L.S., M. Sackler, R.I. Brezinschek, E. Lightfoot, J.L. Bailey, N. Oppenheimer-Marks, P.E. Lipsky, "Inflammation, immune reactivity, and angiogenesis in a SCID model of rheumatoid arthritis" Amer. J. Pathol., 160:357-367, 2002
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